HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4
نویسندگان
چکیده
From the Departments of Medical Information, Respiratory Diseases, and Radiology, Montpellier University Hospital, Montpellier, France; PhyMedExp, University of Montpellier, INSERM U1046, Montpellier University Hospital, Montpellier, France; APARD: Association pour l’Assistance et la R ehabilitation a Domicile, Montpellier, France; and the Department of Respiratory Diseases APHM, INSERM Laboratory U1067, Aix-Marseille University, Marseille, France. E-mail: a-bourdin@ chu-montpellier.fr. *These authors contributed equally to this work. Supported by ‘‘Direction Inter-r egionale de la Recherche Clinique—Sud M editerrann ee’’ (Appel d’Offre Interne du GCS MERRI 2011), Montpellier, France (ID RCB: 2011-A01396-35). Disclosure of potential conflict of interest: P. Chanez has received support for a clinical trial from Boehringer Ingelheim; has received grants and personal fees from Almirall, Boehringer Ingelheim, Centocor, GlaxoSmithKline, AstraZeneca, Novartis, TEVA, Chiesi, and Schering Plough; has received personal fees from Merck Sharp and Dohme; and has received grants from AMU. A. Bourdin has board memberships with GlaxoSmithKline, Sanofi, AstraZeneca, Boeringher Ingelheim, Novartis, and Chiesi. The rest of the authors declare that they have no relevant conflicts of interest.
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